SNS314
N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
CAS: 1057249-41-8
Molecular Formula: C18H15ClN6OS2
SNS314 - Names and Identifiers
| Name | N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea |
| Synonyms | SNS314 CS-901 SNS 314 SNS-314 SNS-314 free base 1-(3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea 1-(3-chlorophenyl)-3-(4-(2-(thieno[3,2-d]pyriMidin-4-ylaMino)ethyl)thiazol-2-yl)urea N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]- |
| CAS | 1057249-41-8 |
SNS314 - Physico-chemical Properties
| Molecular Formula | C18H15ClN6OS2 |
| Molar Mass | 430.93 |
| Density | 1.588 |
| Solubility | DMSO:100 mg/mL (232.06 mM) |
| pKa | 6.12±0.70(Predicted) |
| Storage Condition | -20°C |
| In vitro study | SNS-314 potent inhibition of tumor cell lines, the IC50 was 1.8 to 24 nM, independent of the relative Aurora-A of cells or Aurora-B protein levels. SNS-314 inhibiting the phosphorylation of histone H3 at Ser10 site, the mitosis of HCT116 cells was disturbed. Consecutive treatment with SNS-314 and Carboplatin, Gemcitabine, 5-FU, Daunomycin, and SN-38 showed a potentiated antiproliferative effect, and the combination of SNS-314 and Gemcitabine,Docetaxel, or Vincristine showed a synergistic effect. |
| In vivo study | SNS-314 acts on HCT116 colon transplantation tumor and shows obvious and long-lasting anti-cancer effect. SNS-314 at 170 mg/kg for human breast cancer (MDA-MB-231), prostate cancer (PC-3), lung cancer (H1299 and Calu-6), ovarian cancer (A2780), and malignant melanoma (A375) the murine xenografts also showed significant anticancer activity, with tumor growth inhibition rates ranging from 54 to 91%. |
SNS314 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.321 ml | 11.603 ml | 23.205 ml |
| 5 mM | 0.464 ml | 2.321 ml | 4.641 ml |
| 10 mM | 0.232 ml | 1.16 ml | 2.321 ml |
| 5 mM | 0.046 ml | 0.232 ml | 0.464 ml |
Last Update：2024-01-02 23:10:35
SNS314 - Reference Information
| biological activity | SNS-314 is A potent, selective inhibitor of Aurora A, Aurora B, and Aurora C, the IC50 was 9 nM, 31 nM, and 3 nM, respectively, and the effect on Trk A/B, Flt4, Fms, Axl, c-Raf, and DDR2 was slightly weaker. Phase 1. |
| Target | Value |
| Aurora C | 3 nM |
| Aurora A | 9 nM |
| Aurora B | 31 nM |
Last Update：2024-04-09 21:11:58
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Product Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Visit Supplier Webpage Request for quotation
CAS: 1057249-41-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 1057249-41-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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